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Emiel de Jonge's avatar

Add in the fact that many control. Groups are meaningless and do not reflect real life. Wait list is one of the worst examples

But there are more as well. If you take the worst case control group and compare any kind of social talk I think people would to some degree improve.

doctorfrenz's avatar

As I tell medical students, meta-analyses are magic math. Here’s an example:

“The Egger test indicated significant asymmetry of the funnel plot for MDD, SAD, GAD, PTSD, BED, and BIP but not for PAN, PHOB, OCD, BN, and PSY (eAppendix 17 in Supplement 1). Adjustment for publication bias through Duval and Tweedie’s “trim and fill” procedure resulted in smaller SMDs in all disorders (except for PHOB) and suggested that 20% of studies were missed.”

In plain English, there was a lot of publication bias (“significant asymmetry”). This should have prompted a search for unpublished studies (grey literature), however, there’s no evidence that occurred (it requires medical librarians and a lot of time). Instead, some magic math to account for the missing studies was applied

Meta-analyses assume the component studies are simple replications (like a college chemistry assignment where you run the same protocol several times). But they never are, which leads to heterogeneity:

“Heterogeneity was modest (I2 <50%) for BIP and OCD, high (50%-75%) for PAN, BN, BED and PSY, and very high (>75%) for the other 5 disorders.”

It goes on and on

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